Publications

Imaging of macrophage accumulation in solid tumors with ultrasound

Imaging of macrophage accumulation in solid tumors with ultrasound

Alva, A., Kim, C., Premdas, P., Ferry, Y., Lee, H., … Arvanitis, C.
Nature Communications
DOI: https://doi.org/10.1038/s41467-025-61624-1

Controlling the Blood–Brain Barrier
Data-driven feedback augments ultrasound nanotheranostics in brain tumors

Data-driven feedback augments ultrasound nanotheranostics in brain tumors

Lee, H., Menezes, V., Zeng, S., Kim, C., Baseman, C. M., Kim, J. H., … & Arvanitis, C.
BioRxiv
DOI: https://doi.org/10.1101/2025.05.01.651328

Controlling the Blood–Brain Barrier
Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy

Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy

Zamat, A., Kim, C., Sridhar, S., Fabrega, S., Sen, R., Campbell, N., … & Kwong, G. A.
BioRxiv
DOI: https://doi.org/10.1101/2025.04.23.650339

Controlling the Blood–Brain Barrier
Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier

Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier

Guo Y, Lee H, Kim C, Park C, Yamamichi A, Chuntova P, Gallus M, Bernabeu MO, Okada H, Jo H, Arvanitis C.
Nature Communications 15 (1), 8021
DOI: https://doi.org/10.1038/s41467-024-52329-y

Controlling the Blood–Brain Barrier
A high sensitivity CMUT-based passive cavitation detector for monitoring microbubble dynamics during focused ultrasound interventions

A high sensitivity CMUT-based passive cavitation detector for monitoring microbubble dynamics during focused ultrasound interventions

RP Zangabad, H Lee, X Zhang, MS Kilinc, CD Arvanitis, FL Degertekin
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
DOI: 10.1109/TUFFC.2024.3436918

Programming Therapeutic Cells with Sound
CMUT as a Transmitter for Microbubble-Assisted Blood-Brain Barrier Opening

CMUT as a Transmitter for Microbubble-Assisted Blood-Brain Barrier Opening

MS Kilinc, RP Zangabad, C Arvanitis, FL Degertekin
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
DOI: 10.1109/TUFFC.2024.3417818

Programming Therapeutic Cells with Sound
Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade

Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade

H Lee, Y Guo, JL Ross, S Schoen Jr, FL Degertekin, C Arvanitis
Science Advances 8 (46), eadd2288
DOI: 10.1126/sciadv.add2288

Programming Therapeutic Cells with Sound
The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors

The roles of thermal and mechanical stress in focused ultrasound-mediated immunomodulation and immunotherapy for central nervous system tumors

C. Kim, M. Lim, G. F. Woodworth, C. D. Arvanitis
Journal of Neuro-oncology 157 (2), 221-236
DOI: https://doi.org/10.1007/s11060-022-03973-1

Programming Therapeutic Cells with Sound
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound

Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound

Schoen Jr, S., Kilinc, M. S., Lee, H., Guo, Y., Degertekin, F. L., Woodworth, G. F., & Arvanitis, C.
Advanced Drug Delivery Reviews, 180, 114043
DOI: https://doi.org/10.1016/j.addr.2021.114043

Programming Therapeutic Cells with Sound
Experimental Demonstration of Trans-skull Volumetric Passive Acoustic Mapping with the Heterogeneous Angular Spectrum Approach

Experimental Demonstration of Trans-skull Volumetric Passive Acoustic Mapping with the Heterogeneous Angular Spectrum Approach

Schoen, S., Dash, P., & Arvanitis, C. D.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
DOI: 10.1109/TUFFC.2021.3125670

Most Cited Visualizing Immune-Cell Trafficking
Localized blood-brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions-controlled focused ultrasound

Localized blood-brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions-controlled focused ultrasound

P. Anastasiadis, D. Gandhi, Y. Guo, A-K. Ahmed, S.M. Bentzen, C. D. Arvanitis, and F. Woodworth
Proceedings of the National Academy of Sciences, 118 (37), e2103280118
DOI: https://doi.org/10.1073/pnas.2103280118

Most Cited Visualizing Immune-Cell Trafficking
Closed-loop trans-skull ultrasound hyperthermia leads to improved drug delivery from thermosensitive drugs and changes the transvascular transport dynamics in brain tumors

Closed-loop trans-skull ultrasound hyperthermia leads to improved drug delivery from thermosensitive drugs and changes the transvascular transport dynamics in brain tumors

C. Kim, Y. Guo, A. Velalopoulou, J. Leisen, A. Motamarry, K. Ramajayam, M. Aryal, D. Haemmerich, and C. D. Arvanitis
Theranostics, 11(15):7276-7293
DOI: 10.7150/thno.54630

Most Cited Visualizing Immune-Cell Trafficking
Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles

Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles

Y. Guo, H. Lee, Z. Fang, A. Velalopoulou, J. Kim, B. Thomas, T. Kim, A. F. Coskun, D. P. Krummel, S. Sengupta, T. McDannold, and C. D. Arvanitis
Science Advances, 7, eabf7390
DOI: DOI: 10.1126/sciadv.abf7390

Most Cited Visualizing Immune-Cell Trafficking
Morphological reconstruction improves microvessel mapping in super-resolution ultrasound

Morphological reconstruction improves microvessel mapping in super-resolution ultrasound

S. J. Schoen, Z. Zhao, A. Alva, C. Huang, S. Chen and C. D. Arvanitis
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 68(6): 2141–2149
DOI: 10.1109/TUFFC.2021.3057540

Most Cited Visualizing Immune-Cell Trafficking