Integrating multiscale physics, Fourier acoustics, and mathematical modeling to map acoustic fields.
Our laboratory develops fundamental wave propagation models to map acoustic fields and microbubble dynamics through complex,
Understanding and exploiting intracellular microbubble dynamics to image immune-cell trafficking in vivo.
Monitoring immune-cell trafficking remains challenging because it requires high sensitivity and specificity while preserving spatial resolution and ability to image at different depth.
Harnessing closed-loop MRgFUS hyperthermia and thermal bioswitches for spatiotemporal regulation of immunotherapy.
In collaboration with the Kwong Lab, our laboratory pioneered a closed-loop sonothermogenetic strategy for the remote,
Investigating how acoustic forces regulate vascular biology, mechanosensitive signaling, and immune-cell function.
Our laboratory investigates how microbubble (MB)-generated mechanical forces regulate vascular biology. We showed that ultrasound excitation just above MB resonance maximizes vessel wall shear stress and regulates the enrichment of inflammatory pathways responsive to wall shear stress (Nature Communications 2024).
